Room Temperature Palladium-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes
Forrest E. Michael* and Brian M. Cochran
*University of Washington, Box 351700, Seattle, Washington 98195-1700, Email:
michael
chem.washington.edu
F. E. Michael, B. M. Cochran, J. Am. Chem. Soc., 2006, 128, 4246-4247.
DOI: 10.1021/ja060126h
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Abstract
A mild and facile Pd-catalyzed intramolecular hydroamination of unactivated alkenes takes place at room temperature and tolerates acid-sensitive functional groups. The tridentate ligand on Pd effectively inhibits β-hydride elimination, thus the formation of hydroamination products is preferred over oxidative amination products.
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Key Words
ID: J48-Y2006-1790
