Organic Chemistry Portal

Abstracts

Search:

Synthesis of Substituted Pyridine Derivatives via the Ruthenium-Catalyzed Cycloisomerization of 3-Azadienynes

Mohammad Movassaghi* and Matthew D. Hill

*Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, Email: movassagmit.edu

M. Movassaghi, M. D. Hill, J. Am. Chem. Soc., 2006, 128, 4592-4593.

DOI: 10.1021/ja060626a (free Supporting Information)


Abstract

The direct conversion of amides, including sensitive N-vinyl amides, to the corresponding trimethylsilyl alkynyl imines followed by a ruthenium-catalyzed protodesilylation and cycloisomerization gives various substituted pyridines and quinolines.

see article for more examples



Single-Step Synthesis of Pyridine Derivatives

M. Movassaghi, M. D. Hill, O. K. Ahmad, J. Am. Chem. Soc., 2007, 129, 10096-10097.


Key Words

Imines, Pyridines, Quinolines


ID: J48-Y2006-1880