Synthesis of Substituted Pyridine Derivatives via the Ruthenium-Catalyzed Cycloisomerization of 3-Azadienynes
Mohammad Movassaghi* and Matthew D. Hill
*Massachusetts Institute of Technology, Department of Chemistry, Cambridge,
Massachusetts 02139, Email: movassag
mit.edu
M. Movassaghi, M. D. Hill, J. Am. Chem. Soc., 2006, 128, 4592-4593.
DOI: 10.1021/ja060626a
Abstract
The direct conversion of amides, including sensitive N-vinyl amides, to the corresponding trimethylsilyl alkynyl imines followed by a ruthenium-catalyzed protodesilylation and cycloisomerization gives various substituted pyridines and quinolines.
see article for more examples
Single-Step Synthesis of Pyridine Derivatives
M. Movassaghi, M. D. Hill, O. K. Ahmad, J. Am. Chem. Soc., 2007, 129, 10096-10097.
Key Words
ID: J48-Y2006-1880
