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L-Piperazine-2-carboxylic Acid Derived N-Formamide as a Highly Enantioselective Lewis Basic Catalyst for Hydrosilylation of N-Aryl Imines with an Unprecedented Substrate Profile

Zhouyu Wang, Mounuo Cheng, Pengcheng Wu, Siyu Wei and Jian Sun*

*Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China, Email: sunjiancib.ac.cn

Z. Wang, M. Cheng, P. Wu, S. Wei, J. Sun, Org. Lett., 2006, 8, 3045-3048.

DOI: 10.1021/ol060984i (free Supporting Information)



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Abstract

L-Piperazine-2-carboxylic acid derived N-formamides are highly enantioselective Lewis basic catalysts for the hydrosilylation of imines with trichlorosilane. High isolated yields and enantioselectivities were obtained for a broad range of substrates, including aromatic and aliphatic ketimines.

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A Highly Enantioselective Lewis Basic Organocatalyst for Reduction of N-Aryl Imines with Unprecedented Substrate Spectrum

Z. Wang, X. Ye, S. Wei, P. Wu, A. Zhang, J. Sun, Org. Lett., 2006, 8, 999-1001.


Key Words

Reduction of Imines, Organocatalysis, Trichlorosilane


ID: J54-Y2006-1930