Gold-Catalyzed Intramolecular Carbothiolation of Alkynes: Synthesis of 2,3-Disubstituted Benzothiophenes from (α-Alkoxy Alkyl) (ortho-Alkynyl Phenyl) Sulfides
Itaru Nakamura*, Takuma Sato, Yoshinori Yamamoto
*Department of Chemistry, Graduate School of Science, Tohoku University,
Sendai 980-8578, Japan, Email: itaru-n
mail.tains.tohoku.ac.jp
I. Nakamura, T. Sato, Y. Yamamoto, Angew. Chem. Int. Ed., 2006, 45, 4473-4475.
DOI: 10.1002/anie.200601178 (free Supporting Information)
Abstract
A gold-catalyzed carbothiolation provided an atom-economic way of synthesizing sulfur-containing heterocycles such as 2,3-disubstituted benzothiophenes.
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Key Words
cyclization, gold, homogeneous catalysis, sulfur heterocycles, benzothiophenes, synthetic methods
ID: J06-Y2006-1690
