Air-Stable PinP(O)H as Preligand for Palladium-Catalyzed Kumada Couplings of Unactivated Tosylates
Lutz Ackermann* and Andreas Althammer
*Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität
München, Butenandtstrasse 5-13, D-81377 München, Germany, Email: lutz.ackermann
cup.uni-muenchen.de
L. Ackermann, A. Althammer, Org. Lett., 2006, 8, 3457-3460.
DOI: 10.1021/ol061116o (free Supporting Information)
Abstract
Air-stable and easily accessible PinP(O)H enables highly efficient palladium-catalyzed Kumada cross-coupling reactions of aryl tosylates. The in situ generated catalyst proved applicable not only to electron-rich and electron-poor carbocyclic tosylates but also to heterocyclic tosylates, such as pyridine and quinoline derivatives.
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Key Words
Kumada Coupling, Biaryls, Heterobiaryls
ID: J54-Y2006-2290
