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Highly Selective 1,6-Addition of Aryl Boronic Acids to α,β,γ,δ-Unsaturated Carbonyl Compounds Catalyzed by an Iridium Complex

Takahiro Nishimura, Yuichi Yasuhara, Tamio Hayashi*

*Department of Chemistry, Graduate School of Science, Sakyo, Kyoto 606-8502, Japan, Email:

T. Nishimura, Y. Yasuhara, T. Hayashi, Angew. Chem. Int. Ed., 2006, 45, 5164-5166.

DOI: 10.1002/anie.200601719 (free Supporting Information)


The catalytic iridium-catalyzed 1,6-addition of aryl boronic acids to electron-deficient dienes gave high yields of the corresponding δ-arylated carbonyl compounds with perfect 1,6-selectivity.

see article for more examples

Iridium/Chiral Diene-Catalyzed Asymmetric 1,6-Addition of Arylboroxines to α,β,γ,δ-Unsaturated Carbonyl Compounds

T. Nishimura, Y. Yashuhara, T. Sawano, T. Hayashi, J. Am. Chem. Soc., 2010, 132, 7872-7873.

Key Words

1,6-Additions (carbonyl compounds, carboxyl compounds), arylation, boronic acids, iridium, regioselectivity

ID: J06-Y2006-2190