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3,3'-Diphosphoryl-1,1'-bi-2-naphthol-Zn(II) Complexes as Conjugate Acid-Base Catalysts for Enantioselective Dialkylzinc Addition to Aldehydes

Manabu Hatano, Takashi Miyamoto and Kazuaki Ishihara*

*Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan, Email: ishiharacc.nagoya-u.ac.jp

M. Hatano, T. Miyamoto, K. Ishihara, J. Org. Chem., 2006, 71, 6474-6484.

DOI: 10.1021/jo060908t (free Supporting Information)


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Abstract

A highly enantioselective addition of dialkylzincs to aromatic, aliphatic, and heteroaromatic aldehydes is based on conjugate Lewis acid-Lewis base catalysis using bifunctional BINOL ligands.

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Highly Active Chiral Phosphoramide-Zn(II) Complexes as Conjugate Acid-Base Catalysts for Enantioselective Organozinc Addition to Ketones

M. Hatano, T. Miyamoto, K. Ishihara, Org. Lett., 2007, 9, 4535-4538.


Key Words

1,2-Additions


ID: J42-Y2006-2470