Construction of Tetrasubstituted Carbon by an Organocatalyst: Cyanation Reaction of Ketones and Ketimines Catalyzed by a Nucleophilic N-Heterocyclic Carbene
Yoshimasa Fukuda, Kazuhiro Kondo*, Toyohiko Aoyama*
*Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan, Email: kazukphar.nagoya-cu.ac.jp, aoyamaphar.nagoya-cu.ac.jp
Y. Fukuda, K. Kondo, T. Aoyama, Synthesis, 2006, 2649-2652.
An N-heterocyclic carbene as a nucleophilic organocatalyst allows the cyanation of ketones and ketimines with TMSCN in good yields under mild reaction conditions.
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