Aminohydroxyphosphine Ligand for the Copper-Catalyzed Enantioselective Conjugate Addition of Organozinc Reagents
Alakananda Hajra, Naohiko Yoshikai and Eiichi Nakamura*
*Department of Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo
113-0033, Japan, Email: nakamura
chem.s.u-tokyo.ac.jp
A. Hajra, N. Yoshikai, E. Nakamura, Org. Lett., 2006, 8, 4153-4155.
DOI: 10.1021/ol0618306 (free Supporting Information)
Abstract
A new tridentate alanine-derived aminohydroxyphosphine ligand induces consistently high enantioselectivity in copper-catalyzed asymmetric conjugate additions of organozinc reagents to various acyclic enones. A highly ordered transition state is proposed.
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Key Words
ID: J54-Y2006-2660
