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Nickel-Catalyzed Cyclization of 2-Iodoanilines with Aroylalkynes: An Efficient Route for Quinoline Derivatives

Rajendra Prasad Korivi and Chien-Hong Cheng*

*Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, Email:

R. P. Korivi, C.-H. Cheng, J. Org. Chem., 2006, 71, 7079-7082.

DOI: 10.1021/jo060800d (free Supporting Information)


An efficient and convenient nickel-catalyzed cyclization of 2-iodoanilines with alkynyl aryl ketones gives 2,4-disubstituted quinolines. Naturally occurring quinoline derivatives have been prepared in good yields. The mechanism is discussed.

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proposed mechanism

Key Words

Quinolines, Zinc

ID: J42-Y2006-2710