Organic Chemistry Portal

Abstracts

Search:

Brønsted Acid Catalyzed Addition of Phenols, Carboxylic Acids, and Tosylamides to Simple Olefins

Zigang Li, Junliang Zhang, Chad Brouwer, Cai-Guang Yang, Nicholas W. Reich and Chuan He*

*Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, Email: chuanheuchicago.edu

Z. Li, J. Zhang, C. Brouwer, C.-G. Yang, N. W. Reich, C. He, Org. Lett., 2006, 8, 4175-4178.

DOI: 10.1021/ol0610035 (free Supporting Information)


   see article for more reactions

Abstract

A simple addition of phenols, carboxylic acids, and protected amines to olefins can be catalyzed by triflic acid. A low concentration of triflic acid and control of the reaction temperature help to tolerate functional groups, such as methoxyl substitution on aromatics.

see article for more examples



Key Words

Sulfonamides, Aryl ethers


ID: J54-Y2006-2730