Catalytic Enantioselective Decarboxylative Protonation
Justin T. Mohr, Toyoki Nishimata, Douglas C. Behenna and Brian M. Stoltz*
*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Email: stoltzcaltech.edu
J. T. Mohr, T. Nishimata, D. C. Behenna, B. M. Stoltz, J. Am. Chem. Soc., 2006, 128, 11348-11349.
DOI: 10.1021/ja063335a (free Supporting Information)
A highly enantioselective, general catalytic system for the facile synthesis of tertiary stereocenters adjacent to cyclic ketones relies on catalytic decarboxylative protonation of readily accessible racemic quaternary β-ketoesters.
see article for more examples
Development of (Trimethylsilyl)ethyl Ester Protected Enolates and Applications in Palladium-Catalyzed Enantioselective Allylic Alkylation: Intermolecular Cross-Coupling of Functionalized Electrophiles
C. M. Reeves, D. C. Behenna, B. M. Stotz, Org. Lett., 2014, 16, 2314-2317.
J. T. Mohr, D. C. Behenna, A. M. Harned, B. M. Stoltz, Angew. Chem. Int. Ed., 2005, 44, 6924-6927.
decarboxylation, asymmetric catalysis, enolates, palladium