Organic Chemistry Portal

Abstracts

Search:

Oxidative Mannich Reaction of N-Carbobenzyloxy Amines with 1,3-Dicarbonyl Compounds

Jun-ichi Matsuo,* Yumi Tanaki and Hiroyuki Ishibashi

*Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan, Email: jimatsuop.kanazawa-u.ac.jp

J-I. Matsuo, Y. Tanaki, H. Ishibashi, Org. Lett., 2006, 8, 4371-4374.

DOI: 10.1021/ol0618095 (free Supporting Information)


Abstract

Efficient carbon-carbon bond formation of N-carbobenzyloxy amines with 1,3-dicarbonyl compounds at the α-position of nitrogen was established by a one-pot oxidative Mannich reaction using N-tert-butylbenzenesulfinimidoyl chloride as an oxidant.

see article for more examples



Key Words

Mannich Reaction, β-Amino Acids, Active Methylene Compounds, N-tert-Butylbenzenesulfinimidoyl chloride


ID: J54-Y2006-2890