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Efficient Synthesis of Functionalized Organozinc Compounds by the Direct Insertion of Zinc into Organic Iodides and Bromides

Arkady Krasovskiy, Vladimir Malakhov, Andrei Gavryushin, Paul Knochel

*Ludwig Maximilians-Universität München, Department Chemie & Biochemie, Butenandtstrasse 5-13, Haus F, 81377 München, Email: paul.knochelcup.uni-muenchen.de

A. Krasovski, V. Malakhov, A. Gavryushin, P. Knochel, Angew. Chem. Int. Ed., 2006, 45, 6040-6044.

DOI: 10.1002/anie.200601450 (free Supporting Information)


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Abstract

The use of Zn powder in the presence of LiCl in THF allows a simple, high-yielding preparation of a broad range of functionalized aryl- and heteroarylzinc reagents. The synthesis of alkylzinc reagents was performed from inexpensive alkyl bromides.

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Highly Stereoselective Cobalt-Catalyzed Allylation of Functionalized Diarylzinc Reagents

G. Dunet, P. Knochel, Synlett, 2007, 1383-1386.


Key Words

coupling (acylation of arenes, acylations, allylation), homogeneous catalysis, insertion, organozinc compounds, zinc


ID: J06-Y2006-2970