Efficient Solvent-Free Selective Monoalkylation of Arylacetonitriles with Mono-, Bis-, and Tris-primary Alcohols Catalyzed by a Cp*Ir Complex
Christian Löfberg, Ronald Grigg,* Mark A. Whittaker, Ann Keep and Andrew Derrick
*Molecular, Innovation, Diversity, and Automated Synthesis (MIDAS) Centre,
Department of Chemistry, University of Leeds, LS2 9JT, United Kingdom, Email:
r.grigg
leeds.ac.uk
C. Löfberg, R. Grigg, M. A. Whittaker, A. Keep, A. Derrick, J. Org. Chem., 2006, 71, 8023-8027.
DOI: 10.1021/jo061113p (free Supporting Information)
Abstract
A solvent-free [Cp*IrCl2]2-catalyzed reaction of substituted acetonitriles with primary alcohols delivered monosubstituted aryl/heteroaryl acetonitriles in excellent yield. This process can be achieved by conventional or microwave heating.
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proposed reaction pathway
Key Words
ID: J42-Y2006-3130
