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On Water and in Air: Fast and Highly Chemoselective Transfer Hydrogenation of Aldehydes with Iridium Catalysts

Xiaofeng Wu, Jianke Liu, Xiaohong Li, Antonio Zanotti-Gerosa, Fred Hancock, Daniele Vinci, Jiwu Ruan, Jianliang Xiao*

*Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK, Email: j.xiaoliv.ac.uk

X. Wu, J. Liu, X. Li, A. Zanotti-Gerosa, F. Hancock, D. Vinci, J. Ruan, J. Xiao, Angew. Chem. Int. Ed., 2006, 45, 6718-6722.

DOI: 10.1002/anie.200602122 (free Supporting Information)


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Abstract

An on-water Ir(III)-diamine catalysis represents an efficient, simple and environmentally friendly catalytic system for the transfer hydrogenation of aldehydes. The catalyst tolerates various synthetically useful groups including nitro groups, halogens, ketones, esters and olefins.

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Accelerated asymmetric transfer hydrogenation of aromatic ketones in water

X. Wu, X. Li, W. Hems, F. King, J. Xiao, Org. Biomol. Chem., 2004, 2, 1818-1821.


Key Words

aldehydes, enones, chemoselectivity, iridium, transfer hydrogenation, formic acid, water, green chemistry


ID: J06-Y2006-3290