A General and Efficient FeCl3-Catalyzed Nucleophilic Substitution of Propargylic Alcohols
Zhuang-ping Zhan,* Jing-liang Yu, Hui-juan Liu, Yuan-yuan Cui, Rui-feng Yang, Wen-zhen Yang and Jun-ping Li
*Department of Chemistry and The Key Laboratory for Chemical Biology of
Fujian Province, College of Chemistry and Chemical Engineering, Xiamen
University, Xiamen 361005, Email: zpzhan
xmu.edu.cn
Z.-P. Zhan, J.-L. Yu, Y.-Y. Cui, R.-F. Yang, W.-Z. Yang, J.-P. Li, J. Org. Chem., 2006, 71, 8298-8301.
DOI: 10.1021/jo061234p (free Supporting Information)
Abstract
A general and efficient FeCl3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, forms new C-C, C-O, C-S and C-N bonds.
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Key Words
propargylic substitution, ethers, amines, sulfides
ID: J42-Y2006-3370
