Chiral Brønsted Acid-Catalyzed Inverse Electron-Demand Aza Diels-Alder Reaction
Takahiko Akiyama,* Hisashi Morita and Kohei Fuchibe
*Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1
Mejiro, Toshima-ku, 171-8588 Tokyo, Japan, Email: takahiko.akiyama
gakushuin.ac.jp
T. Akiyama, H. Morita, K. Fuchibe, J. Am. Chem. Soc., 2006, 128, 13070-13071.
DOI: 10.1021/ja064676r (free Supporting Information)
Abstract
A chiral BINOL-derived phosphoric acid diester catalyzed an inverse electron-demand aza Diels-Alder reaction of aldimine with enol ethers to give tetrahydroquinoline derivatives with excellent enantioselectivity.
see article for more examples
Key Words
Diels-Alder Reaction, N-Heterocycles, Organocatalysis
ID: J48-Y2006-3380
