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Single-Step Synthesis of Pyrimidine Derivatives

Mohammad Movassaghi* and Matthew D. Hill

*Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, Email: movassagmit.edu

M. Movassaghi, M. D. Hill, J. Am. Chem. Soc., 2006, 128, 14254-14255.

DOI: 10.1021/ja066405m (free Supporting Information)



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Abstract

A single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyrimidine and quinazoline derivatives involves amide activation with 2-chloropyridine and trifluoromethanesulfonic anhydride followed by nitrile addition into the reactive intermediate and cycloisomerization.

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Synthesis of Densely Substituted Pyrimidine Derivatives

O. K. Ahmad, M. D. Hill, M. Movassaghi, J. Org. Chem., 2009, 74, 8460-8463.

Single-Step Synthesis of Pyridine Derivatives

M. Movassaghi, M. D. Hill, O. K. Ahmad, J. Am. Chem. Soc., 2007, 129, 10096-10097.

A Versatile Cyclodehydration Reaction for the Synthesis of Isoquinoline and β-Carboline Derivatives

M. Movassaghi, M. D. Hill, Org. Lett., 2008, 10, 3485-3488.


Key Words

Pyrimidines


ID: J48-Y2006-3560