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N-Heterocyclic Carbene: An Efficient Catalyst for the Ring-Opening Reaction of Aziridine with Acid Anhydride

Xiaoyu Sun, Shengqing Ye, Jie Wu*

*Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China, Email: jie_wufudan.edu.cn

X. Sun, S. Ye, J. Wu, Eur. J. Org. Chem., 2006, 4787-4790.

DOI: 10.1002/ejoc.200600663


Abstract

A N-heterocyclic carbene serves as an efficient catalyst for the regioselective ring-opening reactions of aziridines in the presence of acid anhydrides to afford the desired products in good to excellent yields.

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Key Words

Aziridines, N-Heterocyclic carbenes, Acid anhydrides, Organocatalysis, 1,2-amino alcohols


ID: J24-Y2006-3570