Stereoselective Synthesis of β-Amino Ketones via Direct Mannich-Type Reactions, Catalyzed with ZrOCl2 · 8 H2O under Solvent-Free Conditions
Bagher Eftekhari-Sis, Amir Abdollahifar, Mohammed M. Hashemi*, Maryam Zirak
*Department of Chemistry, Sharif University of Technology, P. O. Box 11365-9516, Tehran, Iran, Email: mhashemisharif.edu
B. Eftekhari-Sis, A. Abdollahifar, M. M. Hashemi, M. Zirak, Eur. J. Org. Chem., 2006, 5152-5157.
DOI: 10.1002/ejoc.200600493 (free Supporting Information)
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At room temperature, zirconium oxychloride efficiently catalyzes the direct Mannich-type three-component reaction of aldehydes and anilines with ketones under solvent-free conditions to afford the β-amino ketones in good yields with good stereoselectivities. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.
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