Organic Chemistry Portal

Abstracts

Search:

Stereoselective Synthesis of β-Amino Ketones via Direct Mannich-Type Reactions, Catalyzed with ZrOCl2 8 H2O under Solvent-Free Conditions

Bagher Eftekhari-Sis, Amir Abdollahifar, Mohammed M. Hashemi*, Maryam Zirak

*Department of Chemistry, Sharif University of Technology, P. O. Box 11365-9516, Tehran, Iran, Email: mhashemisharif.edu

B. Eftekhari-Sis, A. Abdollahifar, M. M. Hashemi, M. Zirak, Eur. J. Org. Chem., 2006, 5152-5157.

DOI: 10.1002/ejoc.200600493 (free Supporting Information)


see article for more reactions

Abstract

At room temperature, zirconium oxychloride efficiently catalyzes the direct Mannich-type three-component reaction of aldehydes and anilines with ketones under solvent-free conditions to afford the β-amino ketones in good yields with good stereoselectivities. The catalyst can be recycled for subsequent reactions without any appreciable loss of efficiency.

see article for more examples



Key Words

Mannich Reaction, β-Amino Ketones, Multicomponent Reactions


ID: J24-Y2006-3870