An Efficient Base-Free N-Arylation of Imidazoles and Amines with Arylboronic Acids Using Copper-Exchanged Fluorapatite

M. Lakshmi Kantam,* Gopaldasu T. Venkanna, Chidara Sridhar, Bojja Sreedhar and Boyapati M. Choudary

*Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India, E-mail: mlakshmiiict.res.in

M. L. Kantam, G. T. Venkanna, C. Sridhar, B. Sreedhar, B. M. Choudary, J. Org. Chem., 2006, 71, 9522-9524.

DOI: 10.1021/jo0614036

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Abstract

N-Arylation of imidazoles and amines with arylboronic acids catalyzed by copper-exchanged fluorapatite (CuFAP) in methanol at room temperature gave N-arylimidazoles and N-arylamines in good yields. The use of various arylboronic acids demonstrated the versatility of the reaction.

see article for more examples

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Copper(I) Oxide Catalyzed N-Arylation of Azoles and Amines with Arylboronic Acid at Room Temperature under Base-Free Conditions

B. Sreedhar, G. T. Venkanna, K. B. S. Kumar, V. Balasubrahmanyam, Synthesis, 2008, 795-799.

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Key Words

Chan-Lam Coupling, Arylation (Heterocycles, Anilines)

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ID: J42-Y2006-3950