One-Step Conversion of Pyridine N-Oxides to Tetrazolo[1,5-a]pyridines
John M. Keith*
*Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 3210
Merryfield Row, San Diego, California 92121, E-mail:
jkeith
prdus.jnj.com
J. M. Keith, J. Org. Chem., 2006, 71, 9540-9543.
DOI: 10.1021/jo061819j (free Supporting Information)
Abstract
Pyridine N-oxides were converted to tetrazolo[1,5-a]pyridines in good yield in the presence of sulfonyl or phosphoryl azides and pyridine by heating in the absence of solvent. Diphenyl phosphorazidate (DPPA) was the most convenient reagent.
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Key Words
tetrazolo[1,5-a]pyridines, tetrazoles
ID: J42-Y2006-3990
