Sulfonyl Chloride Formation from Thiol Derivatives by N-Chlorosuccinimide Mediated Oxidation
Atsuko Nishiguchi*, Kazuhiro Maeda, Shokyo Miki
*Chemical Development Laboratories, Takeda Pharmaceutical Company Limited,
2-17-85 Jusohonmachi, Yodogawa-ku, Osaka 532-8686, Japan, Email:
Nishiguchi_Atsuko
takeda.co.jp
A. Nishiguchi, K. Maeda, S. Miki, Synthesis, 2006, 4131-4134.
Abstract
A smooth oxidation of several thiol derivatives by a combination of N-chlorosuccinimide and dilute hydrochloric acid afforded the corresponding sulfonyl chlorides in good yield.
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Key Words
thiol derivatives, oxidation, solvent effects, NCS, chlorosulfonation
ID: J66-Y2006-4040
