Suzuki-Miyaura Cross-Coupling Reactions of Potassium Vinyltrifluoroborate with Aryl and Heteroaryl Electrophiles

Gary A. Molander* and Adam R. Brown

*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, E-mail: gmolandrsas.upenn.edu

G. A. Molander, A. R. Brown, J. Org. Chem., 2006, 71, 9681-9686.

DOI: 10.1021/jo0617013 (free Supporting Information)

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Abstract

The palladium-catalyzed cross-coupling reaction of potassium vinyltrifluoroborate with aryl electrophiles can generally be effected using 2 mol % of PdCl₂ and 6 mol % of PPh₃ as a catalyst system in THF/H₂O with Cs₂CO₃ as a base. Good yields are obtained in the presence of various functional groups.

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Suzuki-Miyaura Cross-Coupling Reactions of Potassium Alkenyltrifluoroborates

G. A. Molander, C. R. Bernardi, J. Org. Chem., 2002, 67, 8424-8429.

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Key Words

Potassium alkenyltrifluoroborates, Suzuki Coupling, Olefination

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ID: J42-Y2006-4080