Iridium-Catalyzed C-C Bond Forming Hydrogenation: Direct Regioselective Reductive Coupling of Alkyl-Substituted Alkynes to Activated Ketones
Ming-Yu Ngai, Andriy Barchuk and Michael J. Krische*
*Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, Email: mkrischemail.utexas.edu
M.-Y. Ngai, A. Barchuk, M. J. Krische, J. Am. Chem. Soc., 2007, 129, 280-281.
DOI: 10.1021/ja0670815 (free Supporting Information)
An iridium-catalyzed, hydrogen-mediated reductive C-C bond formation of alkynes in the presence of α-ketoesters affords β,γ-unsaturated α-hydroxyesters in excellent yield, with complete control of olefin geometry and, in most cases, with excellent regiocontrol.
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J.-R. Kong, M.-Y. Ngai, M. J. Krische, J. Am. Chem. Soc., 2006, 128, 718-719.