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Iridium-Catalyzed Conversion of Alcohols into Amides via Oximes

Nathan A. Owston, Alexandra J. Parker and Jonathan M. J. Williams*

*Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, U.K., Email: j.m.j.williamsbath.ac.uk

N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 73-75.

DOI: 10.1021/ol062549u (free Supporting Information)


Abstract

[Ir(Cp*)Cl2]2 catalyzes the rearrangement of oximes to furnish amides. An iridium-catalyzed transfer hydrogenation between alcohols and styrene and the subsequent formation of an oxime allows the conversion of alcohols into amides in a one-pot process.

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Highly Efficient Ruthenium-Catalyzed Oxime to Amide Rearrangement

N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 3599-3601.


Key Words

amides, rearrangements, oximes, styrene


ID: J54-Y2007-0110