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Application of the Chiral Bis(phosphine) Monoxide Ligand to Catalytic Enantioselective Addition of Dialkylzinc Reagents to β-Nitroalkenes

Alexandre Côté, Vincent N. G. Lindsay and André B. Charette*

*Département de Chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7, Email: andre.charetteumontreal.ca

A. Côté, V. N. G. Lindsay, A. B. Charette, Org. Lett., 2007, 9, 85-87.

DOI: 10.1021/ol062792t


Abstract

Me-DuPHOS monoxide is a very effective ligand in the enantioselective copper-catalyzed enantioselective addition of dialkylzinc reagents to β-nitroalkenes offering high yields of nitroalkanes, broad and complementary substrate scope, and high enantioselectivities.

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Key Words

Nitro Compounds


ID: J54-Y2007-0130