Niobium Fluoride (NbF5): A Highly Efficient Catalyst for Solvent-Free Cyanosilylation of Aldehydes
Sung Soo Kim*, Gurusamy Rajagopal
*Department of Chemistry, Inha University, Incheon 402-751, South Korea, Email: sungsooinha.ac.kr
S. S. Kim, G. Rajagopal, Synthesis, 2007, 215-218.
An efficient, simple and mild method enables a cyano transfer from trimethylsilylcyanide (TMSCN) to aldehydes within 10 minutes at room temperature in the presence of 0.5 mol% of dispersed NbF5 as the catalyst under solvent-free conditions giving cyanohydrins in excellent yields.
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S. S. Kim, D. W. Kim, G. Rajagopal, Synthesis, 2004, 213-216.