Amine-Promoted, Organocatalytic Aziridination of Enones
Alan Armstrong,* Carl A. Baxter, Scott G. Lamont, Andrew R. Pape and Richard Wincewicz
*Department of Chemistry, Imperial College London, South Kensington, London,
SW7 2AZ, United Kingdom, Email: a.armstrong
imperial.ac.uk
A. Armstrong, C. A. Baxter, S. G. Lamont, A. R. Pape, R. Wincewicz, Org. Lett., 2007, 9, 351-353.
DOI: 10.1021/ol062852v (free Supporting Information)
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Abstract
N-N ylides for the aziridination of a range of enone systems can be prepared by in situ amination of a tertiary amine. The amine may be used sub-stoichiometrically, and promising levels of enantioselectivity are observed with quinine as promoter.
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proposed mechanism
Key Words
ID: J54-Y2007-0230
