A Novel and Efficient Synthesis of Unsymmetrical Disulfides
Sylwia Antoniow, Dariusz Witt*
*Department of Organic Chemistry, Chemical Faculty, Gdansk University of
Technology, Narutowicza 11/12, 80-952 Gdansk, Poland,
Email: dwitt
chem.pg.gda.pl
S. Antoniow, D. Witt, Synthesis, 2007, 363-366.
Abstract
Unsymmetrical disulfides have been prepared from the corresponding thiols and bis-(5,5-dimethyl-2-thiono-1,3,2-dioxaphosphorinanyl)disulfide under mild conditions with very good yields. This method can be applied to thiols bearing neutral, aromatic, basic or acidic functionalities with variable length of carbon chain.
see article for more examples
Functionalization of Cysteine Derivatives by Unsymmetrical Disulfide Bond Formation
M. Szymelfejnik, S. Demkowicz, J. Rachon, D. Witt, Synthesis, 2007, 3528-3534.
Key Words
disulfides, alkanethiols, l-cysteine, thiophenol
ID: J66-Y2007-0290
