Palladium-Catalyzed Aryl-Aryl Cross-Coupling Reaction Using ortho-Substituted Arylindium Reagents

Miguel A. Pena, José Pérez Sestelo* and Luis A. Sarandeses*

*Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain, Email: qfsarandudc.es, sesteloudc.es

M. A. Pena, J. P. Sestelo, L. A. Sarandeses, J. Org. Chem., 2007, 72, 1271-1275.

DOI: 10.1021/jo062148s (free Supporting Information)

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Abstract

A range of biaryl compounds can be efficiently prepared in high yields by a palladium-catalyzed cross-coupling reaction between ortho-substituted triarylindium reagents and aryl halides. The triarylindium reagents are prepared by directed ortho-lithiation and transmetallation to indium from the corresponding benzene derivatives.

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Key Words

directed ortho metalation, biaryls, heterobiaryls, indoles

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ID: J42-Y2007-0480