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Catalytic Asymmetric Alkylation of α-Cyanocarboxylates Using a Phase-Transfer Catalyst

Kazuhiro Nagata, Daisuke Sano, Takashi Itoh*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, Email: itoh-tpharm.showa-u.ac.jp

K. Nagata, D. Sano, T. Itoh, Synlett, 2007, 547-550.

DOI: 10.1055/s-2007-967963



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Abstract

A highly enantioselective catalytic alkylation of cyanoacetates was achieved using a chiral phase-transfer catalyst to give α,α-disubstituted α-cyanoacetates which have a chiral quaternary carbon.

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Key Words

organocatalysis, phase-transfer catalysis, asymmetric synthesis, alkylation, allylation, benzylations, halides


ID: J60-Y2007-0550