Lawesson's Reagent and Microwaves: A New Efficient Access to Benzoxazoles and Benzothiazoles from Carboxylic Acids under Solvent-Free Conditions

Julio A. Seijas*, M. Pilar Vázquez-Tato*, M. Raquel Carballido-Reboredo, José Crecente-Campo, Lucía Romar-López

*Departamento de Química Orgánica, Universidad de Santiago de Compostela, Facultad de Ciencias, Aptdo. 280, 27080 Lugo, Spain, Email: qoseijaslugo.usc.es, pilarvtlugo.usc.es

J. A. Seijas, M. P. Vázquez-Tato, M. R. Carballido-Reboredo, J. Crecente-Campo, L. Romar-López, Synlett, 2007, 313-316.

DOI: 10.1055/s-2007-967994

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Abstract

Lawesson's reagent is an efficient promoter in the solvent-free microwave-assisted synthesis of 2-substituted benzoxazoles and benzothiazoles from carboxylic acids and 2-aminophenol or 2-aminothiophenol, respectively. Various aromatic, heteroaromatic and aliphatic carboxylic acids react under the conditions developed with good yields.

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Key Words

benzothiazoles, benzoxazoles, Lawesson's reagent, microwave synthesis, thiobenzoic acid

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ID: J60-Y2007-0810