Iron-Catalyzed Arylmagnesiation of Aryl(alkyl)acetylenes in the Presence of an N-Heterocyclic Carbene Ligand
Takafumi Yamagami, Ryo Shintani, Eiji Shirakawa,* and Tamio Hayashi*
*Department of Chemistry, Graduate School of Science, Kyoto University,
Sakyo, Kyoto 606-8502, Japan1, Email: thayashi
kuchem.kyoto-u.ac.jp,
shirakawakuchem.kyoto-u.ac.jp
T. Yamagami, R. Shintani, E. Shirakawa, T. Hayashi, Org. Lett., 2007, 9, 1045-1048.
DOI: 10.1021/ol063132r (free Supporting Information)
Abstract
Addition of arylmagnesium bromides to aryl(alkyl)acetylenes gave high yields of the corresponding alkenylmagnesium reagents in the presence of an iron catalyst and a N-heterocyclic carbene ligand. Subsequent treatment with electrophiles allows the formation of tetrasubstituted alkenes.
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Key Words
ID: J54-Y2007-0900
