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Low-Valent Niobium-Catalyzed Reduction of α,α,α-Trifluorotoluenes

Kohei Fuchibe, Yoshitaka Ohshima, Ken Mitomi and Takahiko Akiyama*

*Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro Toshima-ku, Tokyo 171-8588, Japan, Email: takahiko.akiyamagakushuin.ac.jp

K. Fuchibe, Y. Ohshima, K. Mitomi, T. Akiyama, Org. Lett., 2007, 9, 1497-1499.

DOI: 10.1021/ol070249m (free Supporting Information)


Abstract

Trifluoromethyl arenes were reduced with lithium aluminum hydride to give toluene derivatives in good yields in the presence of 5 mol % of niobium(V) chloride. Stepwise, partial reduction of a bis(trifluoromethyl) arene  was also demonstrated.

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Key Words

Dehalogenation, Niobium, Lithium Aluminium Hydride


ID: J54-Y2007-1080