Alkylation of H-Phosphinate Esters under Basic Conditions
Isabelle Abrunhosa-Thomas, Claire E. Sellers and Jean-Luc Montchamp*
*Department of Chemistry, Texas Christian University, TCU Box 298860, Fort
Worth, Texas 76129, Email: j.montchamp
tcu.edu
I. Abrunhosa-Thomas, C. E. Sellers, J.-L. Montchamp, J. Org. Chem., 2007, 72, 2851-2856.
DOI: 10.1021/jo062436o (free Supporting Information)
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Abstract
Deprotonation of various H-phosphinate esters with LHMDS at low temperature and subsequent alkylation takes place with a wide range of electrophiles. The approach can be employed to access some GABA analogues. The isolated yields are moderate to good.
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Key Words
ID: J42-Y2007-1110
