Synthesis of Pyrroles via Copper-Catalyzed Coupling of Amines with Bromoenones
Yuanjia Pan, Hongjian Lu, Yewen Fang, Xinqiang Fang, Liqun Chen, Junlu Qian, Junhua Wang, Chaozhong Li*
*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. of China, Email: cligmail.sioc.ac.cn
Y. Pan, H. Lu, Y. Fang, X. Fang, L. Chen, J. Qian, J. Wang, C. Li, Synthesis, 2007, 1242-1246.
The CuI/N,N-dimethylglycine-catalyzed reaction of amines with γ-bromo-substituted γ,δ-unsaturated ketones in the presence of K3PO4 and NH4OAc gave the corresponding polysubstituted pyrroles in very good yields.
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