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Efficient Conversion of Aromatic Amines into Azides: A One-Pot Synthesis of Triazole Linkages

Karine Barral, Adam D. Moorhouse and John E. Moses*

*School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom, Email: john.mosesnottingham.ac.uk

K. Barral, A. D. Moorhouse, J. E. Moses, Org. Lett., 2007, 9, 1809-1811.

DOI: 10.1021/ol070527h (free Supporting Information)


Abstract

The synthesis of aromatic azides from the corresponding amines is accomplished under mild conditions with tert-butyl nitrite and azidotrimethylsilane. 1,4-Disubstituted 1,2,3-triazoles were obtained in excellent yields from various aromatic amines without the need for isolation of the azide intermediates.

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Microwave Enhancement of a 'One-Pot' Tandem Azidation-'Click' Cycloaddition of Anilines

A. D. Moorhouse, J. E. Moses, Synlett, 2008, 2089-2092.


Key Words

Azides, Triazoles, Click Chemistry, tert-Butyl nitrite


ID: J54-Y2007-1340