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Synthesis of a Fluorous Ligand and Its Application for Asymmetric Addition of Dimethylzinc to Aldehydes

Yasser S. Sokeirik, Hiroyuki Mori, Masaaki Omote, Kazuyuki Sato, Atsushi Tarui, Itsumaro Kumadaki and Akira Ando*

*Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata, 573-0101 Japan, Email: aandopharm.setsunan.ac.jp

Y. S. Sokeirik, H. Mori, M. Omote, K. Sato, A. Tarui, I. Kumadaki, A. Ando, Org. Lett., 2007, 9, 1927-1929.

DOI: 10.1021/ol070466n (free Supporting Information)


Abstract

A new fluorous ligand showed excellent asymmetric induction on the addition of dimethylzinc to aldehydes. This ligand can be conveniently recycled and will be useful for synthesis of bioactive compounds with a methyl carbinol moiety.

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Key Words

Addition, FPOS, Fluorous


ID: J54-Y2007-1400