A Facile Approach to the Synthesis of Chiral 2-Substituted Benzofurans
Lidia De Luca, Giampaolo Giacomelli* and Giammario Nieddu
*Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2,
I-07100 Sassari, Italy, Email: ggp
uniss.it
L. De Luca, G. Giacomelli, G. Nieddu, J. Org. Chem., 2007, 72, 3955-3957.
DOI: 10.1021/jo070142c (free Supporting Information)
Abstract
An effective and mild microwave-assisted route to 2-substituted benzofurans directly from carboxylic acids allows the preparation of α-alkyl-2-benzofuranmethanamines from N-protected α-amino acids without racemization in good yields.
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reaction pathway
Key Words
Benzofurans, Microwave Synthesis
ID: J42-Y2007-1440
