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An Efficient and Chemoselective Iron Catalyst for the Hydrogenation of Ketones

Charles P. Casey* and Hairong Guan

*Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, Email: caseychem.wisc.edu

C. P. Casey, H. Guan, J. Am. Chem. Soc., 2007, 129, 5816-5817.

DOI: 10.1021/ja071159f (free Supporting Information)


Abstract

An iron complex containing electronically coupled acidic and hydridic hydrogens catalyzes the hydrogenation of ketones under mild conditions and shows high chemoselectivity for aldehydes, ketones, and imines. Isolated carbon double and triple bonds, aryl halides, nitrates, epoxides, and ester functions are unaffected by the hydrogenation conditions.

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Key Words

reduction of carbonyl compounds, iron (low valent), hydrogen


ID: J48-Y2007-1450