Guanidine/Pd(OAc)2-Catalyzed Room Temperature Suzuki Cross-Coupling Reaction in Aqueous Media under Aerobic Conditions
Shenghai Li, Yingjie Lin, Jungang Cao and Suobo Zhang*
*State Key Laboratory of Polymer and Chemistry, Changchun Institute of
Applied Chemistry, Changchun 130022, China, Email: sbzhang
ciac.jl.cn
S. Li, Y. Lin, J. Cao, S. Zhang, J. Org. Chem., 2007, 72, 4067-4072.
DOI: 10.1021/jo0626257
Abstract
A highly efficient, air-stable catalyst Pd(OAc)2/guanidine couples arylboronic acids with a wide range of aryl halides in aqueous solvent at room temperature to afford biaryls in good to excellent yields. Furthermore, this mild protocol tolerates a broad range of functional groups.
see article for more examples
S. Li, Y. Lin, H. Xie, S. Zhang, J. Xu, Org. Lett., 2006, 8, 391-394.
Key Words
Suzuki Coupling, Biaryls, Green Chemistry
ID: J42-Y2007-1520
