Catalytic Asymmetric Formation of β-Sultams
Marian Zajac and René Peters*
*Laboratory of Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Strasse 10,
Hönggerberg HCI E 111, CH-8093 Zürich, Switzerland, Email: peters
org.chem.ethz.ch
M. Zajac, R. Peters, Org. Lett., 2007, 9, 2007-2010.
DOI: 10.1021/ol070644c (free Supporting Information)
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Abstract
Highly strained β-sultams, sulfonyl analogues of β-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. β-Sultams are practical precursors of highly enantioenriched β-aminosulfonyl derivatives of biological interest.
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proposed mechanism
Key Words
ID: J54-Y2007-1530
