Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines
Bin Liu, Shou-Fei Zhu, Wei Zhang, Chao Chen and Qi-Lin Zhou*
*State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai
University, Tianjin 300071, China, Email: qlzhou
nankai.edu.cn
B. Liu, S.-F. Zhu, W. Zhang, C. Chen, Q.-L. Zhou, J. Am. Chem. Soc., 2007, 129, 5834-5835.
DOI: 10.1021/ja0711765 (free Supporting Information)
Abstract
A highly efficient copper-catalyzed asymmetric insertion of α-diazoesters into N-H bonds using chiral spiro bisoxazoline ligands affords α-amino acid derivatives in high yields with excellent enantioselectivities.
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Key Words
α-Amino Acid Derivatives, Diazoesters
ID: J48-Y2007-1570
