Highly Stereoselective Cobalt-Catalyzed Allylation of Functionalized Diarylzinc Reagents
Guillaume Dunet, Paul Knochel*
*Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, 81377 München, Germany, Email: Paul.Knochelcup.uni-muenchen.de
G. Dunet, P. Knochel, Synlett, 2007, 1383-1386.
Functionalized diarylzinc reagents react readily with allylic chlorides or phosphates in the presence of Co(acac)2 as catalyst to give the SN2 products in high yields and with retention of the double-bond configuration. Functionalities such as ester, ketone, or cyano are tolerated.
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A. Krasovski, V. Malakhov, A. Gavryushin, P. Knochel, Angew. Chem. Int. Ed., 2006, 45, 6040-6044.
catalysis, allylation, cobalt catalysis, organozinc reagents