Palladium-Catalyzed Cross-Coupling Reactions of Substituted Aryl(dimethyl)silanols
Scott E. Denmark*, Michael H. Ober
*Roger Adams Laboratory, Department of Chemistry University
of Illinois, Urbana, Illinois 61801, Email: denmark
scs.uiuc.edu
S. E. Denmark, M. H. Ober, Adv. Synth. Catal., 2004, 346, 1703-1715.
DOI: 10.1002/adsc.200404204
Abstract
Cesium carbonate and cesium hydroxide monohydrate are effective activators for the palladium-catalyzed cross coupling of electron-rich aryl(dimethyl)silanols with aryl iodides and aryl bromides. Extensive optimization led to the identification of key variables such as solvent, catalyst, and hydration level.
see article for more examples
S. E. Denmark, R. C. Smith, W.-T. T. Chang, J. M. Muhuhi, J. Am. Chem. Soc., 2008, 131, 3104-3118.
Key Words
Hiyama-Denmark Coupling, biaryls, C-C bond formation, cesium carbonate, cesium hydroxide, fluoride-free, hydration effect
ID: JXX-Y2004-2460
