Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium
Vishnu Maya, Monika Raj and Vinod K. Singh*
*Deparment of Chemistry, Indian Institute of Technology
Kanpur, India 208 016, Email: vinodks
iitk.ac.in
V. Maya, M. Raj, V. K. Singh, Org. Lett., 2007, 9, 2593-2595.
DOI: 10.1021/ol071013l (free Supporting Information)
Abstract
Small organic molecules catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in brine. Excellent enantioselectivities and diastereoselectivities with very good yields were obtained by using low catalyst loadings.
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Key Words
Aldol Addition, Organocatalysis, Green Chemistry
ID: J54-Y2007-2060
