New Catalysts for Suzuki-Miyaura Coupling Reactions of Heteroatom-Substituted Heteroaryl Chlorides

Anil S. Guram,* Xiang Wang, Emilio E. Bunel, Margaret M. Faul, Robert D. Larsen and Michael J. Martinelli

*Chemistry Research and Discovery, Amgen Inc., Thousand Oaks, California 91320-1799, Email: aguramamgen.com

A. S. Guram, X. Wang, E. E. Bunel, M. M. Faul, R. D. Larsen, M. J. Martinelli, J. Org. Chem., 2007, 72, 5104-5112.

DOI: 10.1021/jo070341w

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Abstract

New air-stable PdCl₂{PR₂(Ph-R')}₂ complexes, readily prepared from commercial reagents, exhibit unique efficiency as catalysts for the Suzuki-Miyaura coupling reactions of a variety of heteroatom-substituted heteroaryl chlorides with a diverse range of aryl/heteroaryl boronic acids.

see article for more examples

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New Air-Stable Catalysts for General and Efficient Suzuki-Miyaura Cross-Coupling Reactions of Heteroaryl Chlorides

A. S. Guram, A. O. King, J. G. Allen, X. Wang, L. B. Schenkel, J. Chan, E. E. Bunel, M. M. Faul, R. D. Larsen, M. J. Martinelli, P. J. Reider, Org. Lett., 2006, 8, 1787-1789.

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Key Words

heterobiaryls, Suzuki Coupling

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ID: J42-Y2007-2100