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Effective Monoallylation of Anilines Catalyzed by Supported KF

Vittorio Pace, Fernando Martínez, María Fernández, Jose V. Sinisterra and Andrés R. Alcántara*

*Organic and Pharmaceutical Chemistry Department, Pharmacy Faculty, Complutense University, 28040-Madrid, Spain, Email: andresrfarm.ucm.es

V. Pace, F. Martínez, M. Fernández, J. V. Sinisterra, A. R. Alcántara, Org. Lett., 2007, 9, 2661-2664.

DOI: 10.1021/ol070890o (free Supporting Information)


Abstract

KF-Celite is an efficient, inexpensive, noncorrosive, and environmentally friendly catalyst for the allylation of anilines. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, monoallylated products are obtained in high isolated yields in very short reaction times.


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Key Words

Allylation


ID: J54-Y2007-2190