Effective Monoallylation of Anilines Catalyzed by Supported KF
Vittorio Pace, Fernando Martínez, María Fernández, Jose V. Sinisterra and Andrés R. Alcántara*
*Organic and Pharmaceutical Chemistry Department, Pharmacy Faculty, Complutense University, 28040-Madrid, Spain, Email: andresrfarm.ucm.es
V. Pace, F. Martínez, M. Fernández, J. V. Sinisterra, A. R. Alcántara, Org. Lett., 2007, 9, 2661-2664.
DOI: 10.1021/ol070890o (free Supporting Information)
KF-Celite is an efficient, inexpensive, noncorrosive, and environmentally friendly catalyst for the allylation of anilines. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, monoallylated products are obtained in high isolated yields in very short reaction times.
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